Association between the triglyceride glucose index:Chinese visceral adiposity index (TyG-CVAI) and new-onset cardiovascular disease in middle-aged and older adults—insights from the China Health and Retirement Longitudinal Study (CHARLS)
Main finding · New-onset CVDResult — go to the resultHazard ratio 1.64 95% CI 1.35–2.00Authors' conclusion
In this national cohort of middle-aged and older Chinese adults, a higher TyG-CVAI was independently and nonlinearly associated with an increased risk of new-onset CVD, demonstrating superior predictive value over its individual components. The TyG-CVAI may serve as a simple and effective integrated tool for the early identification of high-risk individuals for primary CVD prevention.
Study context
- Population
- Middle-aged and older adults in CHARLS without cardiovascular disease (CVD) at baseline1,221 developed CVD
- Participants
- 7,977 participants
- Exposure
- Highest vs lowest TyG-CVAI quartile
- Outcome
- Incidence of new-onset CVD
Methodological detailsnational cohort, quartile analysis, restricted cubic splines, ROC curve analysis
- National cohort
- Quartile analysis
- Restricted cubic splines
- ROC curve analysis
Main finding
New-onset CVD
Hazard ratio
1.64
95% CI 1.35–2.00
Q4vs Q1
HR 1.64 (95% CI 1.35–2.00)
As reported in the abstract
- Cumulative CVD incidence significantly higher with increasing TyG-CVAI quartiles
- log-rank P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | TyG-CVAI | TyG index | CVAI |
|---|---|---|---|
| Prediction of CVD risk (ROC) | |||
| AUC | 0.6315 | 0.5938 | 0.5851 |
Nonlinear association of TyG-CVAI with CVD risk (RCS)
- Threshold
- 778.62
- Above threshold, per unit increase: HR
- 1.47 (95% CI 1.31-1.64; P < 0.001)
- Below threshold: no significant association
Prediction of CVD risk (ROC)
- TyG-CVAI outperformed triglyceride-glucose (TyG) index and Chinese visceral adiposity index (CVAI) alone
Original publication
Association between the triglyceride glucose index:Chinese visceral adiposity index (TyG-CVAI) and new-onset cardiovascular disease in middle-aged and older adults—insights from the China Health and Retirement Longitudinal Study (CHARLS). Cardiovasc Diabetol. Published 20 January 2026. doi:10.
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