Lipids & metabolic liver disease
Association between the triglyceride-glucose-frailty index and all-cause and cardiovascular mortality in individuals with cardiovascular-kidney-metabolic syndrome: the mediating role of the poverty-income ratio
Authors' conclusion
TyGFI levels in individuals with CKM syndrome are nonlinearly associated with increased all-cause and cardiovascular mortality risk. Additionally, the PIR may partially mediate the TyGFI-mortality relationship, highlighting the possible role of socioeconomic factors.
Study context
- Population
- Participants with cardiovascular-kidney-metabolic (CKM) syndrome, NHANES 2005–2018; mortality via National Death Index to December 31, 2019
- Participants
- 15,044 participants
- Exposure
- Highest vs lowest triglyceride-glucose-frailty index (TyGFI) tertile
- Outcome
- All-cause and CV mortality
- Follow-up
- Median observation 82 months (IQR: 46-123 months)
Methodological detailsNHANES 2005-2018, mediation analysis
- NHANES 2005-2018
- Mediation analysis
Main finding
As reported in the abstract
Each group vs lowest TyGFI tertileEstimate (95% CI)P value
Highest TyGFI tertile
HR (all-cause mortality) 3.14(2.57–3.83)
P < 0.001Highest TyGFI tertile
HR (CV mortality) 3.14(2.18–4.52)
P < 0.001- Deaths from all causes
- 1,103
- CV deaths
- 353
Observational data: associations, not effects.
Further findings
TyGFI continuous, per 1-unit increase
- Increase in all-cause mortality risk
- 56%
- Increase in CV mortality risk
- 52%
Mediation by poverty-income ratio (PIR)
- Proportion mediated, all-cause mortality
- 7.66%
- Proportion mediated, CV mortality
- 8.48%
- Partial mediation
Subgroups
- Consistent associations across demographic strata; significant interaction for marital status
Original publication
Association between the triglyceride-glucose-frailty index and all-cause and cardiovascular mortality in individuals with cardiovascular-kidney-metabolic syndrome: the mediating role of the poverty-income ratio. Cardiovasc Diabetol. Published 25 January 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →