Association between the stress hyperglycemia ratio and elevated blood pressure among U.S. adolescents aged 12–17
Authors' conclusion
This study suggests that higher SHR levels are positively associated with the prevalence of EBP among U.S. adolescents aged 12-17.
Study context
- Population
- U.S. adolescents aged 12–17, National Health and Nutrition Examination Survey (NHANES) 1999–2016543 with elevated blood pressure (EBP)
- Participants
- 3,676 adolescents
- Exposure
- Stress hyperglycemia ratio (SHR) quartiles and per SD increase in SHR
- Outcome
- Elevated blood pressure (EBP)
Methodological detailsweighted multivariable logistic regression, NHANES 1999-2016
- Weighted multivariable logistic regression
- NHANES 1999-2016
Main finding
As reported in the abstract
EBP
Adjusted odds ratio (95% CI)P value
Q4vs Q1
1.90(1.29–2.79)
P < 0.001for trendPer SD increase in SHR
1.17(1.04–1.32)
P = 0.009Observational data: associations, not effects.
Further findings
Restricted cubic spline (RCS) analysis of SHR and EBP
- Significant linear association between SHR and EBP
- p for non-linearity > 0.05
Predictive performance of SHR for EBP (ROC)
- AUC (95% CI 0.699-0.747); modest predictive performance
- 0.723
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association between the stress hyperglycemia ratio and elevated blood pressure among U.S. adolescents aged 12–17. Cardiovasc Diabetol. Published 28 October 2025. doi:10.
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