The relationship between C-reactive protein-triglyceride-glucose index and cardiovascular disease: insights from the China health and retirement longitudinal study (CHARLS)
Authors' conclusion
The CTI, as a composite biomarker reflecting integrated metabolic and inflammatory status, demonstrated a significant positive association with CVD risk. Furthermore, this association exhibited variations across age groups and marital status, indicating the potential utility of CTI as a novel and clinically relevant biomarker for CVD risk stratification.
Study context
- Population
- Middle-aged and older participants, China Health and Retirement Longitudinal Study (CHARLS)CHARLS cohort
- Participants
- 8,084 participants
- Exposure
- Higher vs lower C-reactive protein-triglyceride-glucose index
- Outcome
- Incident CVD
Methodological detailspopulation-based, longitudinal
- Population-based
- Longitudinal
Main finding
As reported in the abstract
Hazard ratio (95% CI)
CTI per one-unit increaseadjusted; 44% higher risk
1.44(1.17–1.78)
Per one-unit increase, as printed
- Q2 vs Q1
- HR 1.23; P for trend < 0.001
- Q3 vs Q1
- HR 1.29; P for trend < 0.001
- Q4 vs Q1
- HR 1.40; P for trend < 0.001
- Participants who developed cardiovascular disease (CVD) during follow-up
- 2,133 (26.39%)
Observational data: associations, not effects.
Further findings
Subgroups
- Stronger associations among participants aged 45-60 years and those who were married
Dose-response (restricted cubic splines (RCS))
- Overall linear relationship between CTI and CVD risk
Predictive performance
- CTI improved reclassification (net reclassification improvement (NRI)/integrated discrimination improvement (IDI)) and discrimination (AUC)
Sensitivity analyses
- Corroborated the primary findings
Original publication
The relationship between C-reactive protein-triglyceride-glucose index and cardiovascular disease: insights from the China health and retirement longitudinal study (CHARLS). Cardiovasc Diabetol. Published 28 October 2025. doi:10.
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