Association between the plasma ceramide and coronary microvascular resistance
Authors' conclusion
A significant nonlinear relationship exists between plasma ceramide and coronary microvascular resistance, which holds important clinical implications for the risk stratification of coronary microvascular disease. New insights into the potential effects of ceramides enhance our understanding of the complex mechanisms underlying coronary microvascular disease and warrant further investigation in a broader population.
Study context
- Population
- Hospitalised patients who underwent both ceramide measurement and coronary angiography; coronary microvascular resistance assessed by Angio-IMR (cumulative over three main coronary arteries)
- Participants
- 225 patients
- Outcome
- Association between plasma ceramide levels and ratios and cumulative coronary microvascular resistance
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Plasma 16:0 ceramide, positive association, standardized β ± SE (P < 0.001)
75.05 ± 8.46
16:0/24:0 ceramide ratio, positive association, standardized β ± SE (P < 0.001)
91.72 ± 20.41
Observational data: associations, not effects.
Further findings
ROC: prediction of coronary microvascular resistance
Optimal cut-off Plasma 16:0 ceramide 0.178 µmol/L · 16:0/24:0 ceramide ratio 0.072
Specificity
Sensitivity
Cumulative coronary microvascular resistance, median
- Median cumulative coronary microvascular resistance
- 48.04 (40.32-56.73)
High cumulative microvascular resistance (logistic regression)
- Plasma 16:0 ceramide, β (P < 0.001)
- 8.03 ± 1.91
- 16:0/24:0 ceramide ratio, β (P = 0.010)
- 9.98 ± 3.88
Subgroup: acute coronary syndrome (ACS)
- Association between plasma ceramide and coronary microvascular resistance trending toward non-significance in ACS
Original publication
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