Association between the insulin resistance and all-cause mortality in patients with moderate and severe aortic stenosis: a retrospective cohort study
Authors' conclusion
Higher IR assessed by the TyG index was associated with a higher risk of all-cause mortality in patients with moderate and severe AS.
Study context
- Population
- Patients with moderate to severe aortic stenosis, First Affiliated Hospital of Sun Yat-Sen University; mean age 67.70 years, 62.8% male
- Participants
- 317 patients
- Exposure
- Triglyceride-glucose (TyG) index and all-cause mortality
- Outcome
- All-cause mortality
- Follow-up
- Median 38.07 months
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
All-cause mortality per-unit increase in TyG index · median 38.07 months
All-cause deaths
84
HR per-unit increase in TyG index, fully adjusted
1.622
95% CI 1.086–2.416p = 0.018
Observational data: associations, not effects.
Further findings
Incremental prediction of mortality adding TyG index to basic risk model
- C-statistic change
- 0.755 to 0.768
- Continuous net reclassification improvement
- 0.299 (95% CI 0.051-0.546, p = 0.017)
- Integrated discrimination improvement (0.001-0.033, p = 0.044)
- 0.017
Original publication
Association between the insulin resistance and all-cause mortality in patients with moderate and severe aortic stenosis: a retrospective cohort study. Cardiovasc Diabetol. Published 2 September 2023. doi:10.
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