Association Between Serum Uric Acid to Creatinine Ratio and Time in Range in Patients With Type 2 Diabetes
Authors' conclusion
An inverted U-shaped association exists between SUA/SCr and TIR in patients with T2DM, suggesting that maintaining SUA/SCr within a certain range may be a protective factor for TIR.
Study context
- Population
- Hospitalized patients with T2D; Time in range (TIR) assessed by continuous glucose monitoring (CGM)
- Participants
- 514 patients
- Exposure
- Serum uric acid (SUA)/SCr ratio and TIR
- Outcome
- Association between SUA/SCr ratio and TIR
Methodological detailshospitalized patients, multivariable adjustment
- Hospitalized patients
- Multivariable adjustment
Main finding
As reported in the abstract
TIR by SUA/SCr (multivariable-adjusted)
Inverted U-shaped association between SUA/SCr and TIR; inflection point SUA/SCr
6.471
Below inflection point: TIR change per 1-unit SUA/SCr increase (β)
1.402
p = 0.0379
Above inflection point: TIR change per 1-unit SUA/SCr increase (β)
−4.406
p = 0.0043
Observational data: associations, not effects.
Further findings
Effect modification of SUA/SCr–TIR association
- Gender, BMI, GLP-1 RA therapy, SGLT2i therapy did not significantly modify association
- P > 0.05 for all
- Age significantly modified association
- P for interaction = 0.0240
SUA/SCr–TIR association, age < 65 years
- Inflection point SUA/SCr
- 6.559
- Below inflection point, no significant association (β)
- 0.796, p = 0.2803
- Above inflection point, significant negative association (β)
- −4.392, p = 0.0059
SUA/SCr–TIR association, age ≥ 65 years
- No significant association
Original publication
Association Between Serum Uric Acid to Creatinine Ratio and Time in Range in Patients With Type 2 Diabetes. Clin Endocrinol (Oxf). Published 14 September 2025. doi:10.
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