Association between serum calcium level and type 2 diabetes: An National Health and Nutrition Examination Survey (NHANES) analysis and Mendelian randomization study
Main finding · T2DResult — go to the resultOdds ratio 1.18 95% CI 1.07–1.30Authors' conclusion
The results of this study suggest that higher serum calcium levels are causally associated with a higher risk of T2D. Further studies are needed to clarify whether intervening in high serum calcium could reduce the risk of T2D.
Study context
- Population
- NHANES participants, 1999–2018cross-sectional analysis
- Participants
- 39,645 participants
- Exposure
- Serum calcium tertiles; genetically predicted serum calcium
- Outcome
- T2D prevalence
Methodological detailsNHANES 1999–2018, two-sample MR, UK Biobank instrumental variables
- NHANES 1999–2018
- Two-sample MR
- UK Biobank instrumental variables
Main finding
T2D
Odds ratio
1.18
95% CI 1.07–1.30
P = 0.001
Highvs Medium
OR 1.18 (95% CI 1.07–1.30); P = 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
T2D risk per genetically predicted higher serum calcium (MR)
- OR (95% CI: 1.01, 1.33), p = 0.031
- 1.16
Original publication
Association between serum calcium level and type 2 diabetes: An NHANES analysis and Mendelian randomization study. Diabet Med. Published 28 March 2023. doi:10.
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