Association Between Particulate Matter Exposure and Thyroid Hormone Levels in Early Childhood: Results From JECS
Authors' conclusion
Using a large sample, the statistical modeling results suggested an opposite association between PM exposure and fT4. However, since this association is very weak, from a clinical and epidemiological point of view, we can entirely ignore the effect of PM exposure on fT4. Therefore, we conclude that PM does not significantly influence thyroid parameters in daily life.
Study context
- Population
- Children aged 2 years and 4 years, Japan Environment and Children's Study3,599 (2 y) and 3431 (4 y)
- Exposure
- Particulate matter (PM) exposure and free T4 (fT4) and TSH levels
- Outcome
- Blood free T4 (fT4) and TSH concentrations
- Follow-up
- 2 to 4 years
Methodological detailsongoing birth cohort, generalized linear model, quantile g-computation
- Ongoing birth cohort
- Generalized linear model
- Quantile g-computation
Main finding
As reported in the abstract
Decrease in fT4 at 4 years per simultaneous 1-quartile increase in PM concentrations at 3 years (significant)
0.011 ng/dL
Observational data: associations, not effects.
Original publication
Association Between Particulate Matter Exposure and Thyroid Hormone Levels in Early Childhood: Results From JECS. J Clin Endocrinol Metab. Published 6 August 2025. doi:10.
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