Association Between Parathyroid Hormone-Related Peptide Levels and Mortality in Patients With Malignancy
Main finding · Mortality (survival) by PTHrP level, adjusted for serum calciumResult — go to the resultHR for mortality 1.68 95% CI 1.03–2.77Authors' conclusion
This study showed an association between PTHrP and mortality in patients with malignancy after adjusting for serum calcium levels.
Study context
- Population
- Patients with malignancy, hypercalcemia (>10 mg/dL) and elevated parathyroid hormone-related protein (PTHrP) (>1.1 pmol/L); median age 70 (61–76) years
- Participants
- 183 patients
- Exposure
- Highest vs lowest PTHrP levels
- Outcome
- Mortality (overall survival after cancer diagnosis, after PTHrP measurement, and 5-year survival rate)
Main finding
As reported in the abstract
Mortality (survival) by PTHrP level, adjusted for serum calcium
HR for mortality
1.68
95% CI 1.03–2.77
P = 0.038
Highest PTHrPvs Lowest PTHrP
HR for mortality 1.68 (95% CI 1.03–2.77); P = 0.038
Observational data: associations, not effects.
Further findings
Association of PTHrP with serum calcium
- PTHrP significantly and linearly associated with serum calcium; correlation coefficient
- 0.06 (95% CI 0.039-0.081; t: 5.69; P < .001)
Baseline PTHrP and corrected calcium
- Median PTHrP, pmol/L
- 5.5 (3.0-10.6)
- Median corrected calcium, mg/dl
- 12.5 (11.5-13.4)
Original publication
Association Between Parathyroid Hormone-Related Peptide Levels and Mortality in Patients With Malignancy. Endocr Pract. Published 10 September 2024. doi:10.
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