Association between non-insulin-based insulin resistance indices and cardiovascular events in patients undergoing percutaneous coronary intervention: a retrospective study
Authors' conclusion
All the four IR indices showed a significant association with MACCEs in female individuals, whereas only TyG-BMI index and METS-IR showed associations in elderly patients. Although the inclusion of these IR indices did not improve the predictive power of basic risk model in either female or elderly patients, METS-IR appears to be the most promising index for secondary prevention of MACCEs and risk stratification in patients undergoing PCI.
Study context
- Population
- Consecutive patients undergoing percutaneous coronary intervention (PCI)1,461 analysed
- Participants
- 2,533 patients
- Exposure
- Non-insulin-based insulin resistance (IR) indices and major adverse cardiac and cerebrovascular events (MACCEs)
- Outcome
- MACCEs (major adverse cardiac and cerebrovascular events)
- Follow-up
- Median 29.8 months
Methodological detailsconsecutive participants, multivariate logistic models, restricted cubic splines
- Consecutive participants
- Multivariate logistic models
- Restricted cubic splines
Main finding
As reported in the abstract
MACCEs · median 29.8 months
Incident MACCEs
195 of 1461 patients
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| MACCEs per 1.0-SD increment, elderly patients (subgroup)TyG-BMI index (per 1.0-SD increment) | 1.24 (1.02–1.50) | P < 0.05 | |
| MACCEs per 1.0-SD increment, elderly patients (subgroup)METS-IR (per 1.0-SD increment) | 1.27 (1.04–1.56) | P < 0.05 | |
| 0.512Odds ratio (log scale) |
MACCEs per 1.0-SD increment, elderly patients (subgroup)
- Significant interactions between age subgroups and TyG-BMI index and metabolic score for insulin resistance (METS-IR), and between sex subgroups and triglyceride and glucose (TyG) index
- Linear relationship between METS-IR and MACCEs in elderly patients (multivariable-adjusted restricted cubic splines (RCS))
MACCEs, female patients (subgroup)
- All IR indices showed significant associations with MACCEs
- Linear relationship between METS-IR and MACCEs in female patients (multivariable-adjusted RCS)
Original publication
Association between non-insulin-based insulin resistance indices and cardiovascular events in patients undergoing percutaneous coronary intervention: a retrospective study. Cardiovasc Diabetol. Published 29 June 2023. doi:10.
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