Association between new‐onset atrial fibrillation and dementia among individuals with type 2 diabetes
Authors' conclusion
New-onset atrial fibrillation was associated with a substantially higher risk of all-cause dementia, Alzheimer's disease and vascular dementia in patients with type 2 diabetes. Our findings highlight the significance of atrial fibrillation management in mitigating the risk of dementia in this demographic.
Study context
- Population
- Patients with T2D from the UK BiobankUK Biobank
- Participants
- 22,989 patients
- Exposure
- New-onset AF vs no AF
- AFn = 2,843
- No AFn = 20,146reference
- Outcome
- All-cause dementia, Alzheimer's disease and vascular dementia (UK Biobank algorithm)
- Follow-up
- Median 12.3 years
Methodological detailstime-varying Cox regression
- Time-varying Cox regression
Main finding
As reported in the abstract
All-cause dementia, Alzheimer's disease and vascular dementia · median 12.3 years
Each group vs no AFEstimate (95% CI)
AF
HR (all-cause dementia) 2.15(1.80–2.57)
AF
HR (Alzheimer's disease) 1.44(1.06–1.96)
AF
HR (vascular dementia) 3.11(2.32–4.17)
- All-cause dementia cases
- 844
- Alzheimer's disease cases
- 342
- Vascular dementia cases
- 246
Observational data: associations, not effects.
Original publication
Association between new‐onset atrial fibrillation and dementia among individuals with type 2 diabetes. Diabetes Obes Metab. Published 14 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →