Association Between Insulin Resistance and Myosteatosis Measured by Abdominal Computed Tomography
Authors' conclusion
In this study, a higher HOMA-IR level was significantly associated with a high risk of myosteatosis.
Study context
- Population
- Large Asian population who had abdominal CT; myosteatosis indices from L3 muscle segmentation (total abdominal muscle area (TAMA), normal-attenuation muscle area (NAMA), low-attenuation muscle area (LAMA), intermuscular adipose tissue (IMAT); NAMA/BMI, LAMA/BMI, NAMA/TAMA)
- Participants
- 18,251 participants
- Exposure
- Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) quartiles
- Outcome
- Lowest NAMA/TAMA quartile, adjusted OR
Main finding
As reported in the abstract
Highest HOMA-IR quartile vs Lowest HOMA-IR quartileAdjusted odds ratio (95% CI)
Men
0.414(0.364–0.471)
Women
0.464(0.384–0.562)
Observational data: associations, not effects.
Further findings
Correlation of HOMA-IR with myosteatosis indices
- NAMA/BMI, men (r)
- −0.233
- NAMA/BMI, women (r)
- −0.265
- NAMA/TAMA, men (r)
- −0.211
- NAMA/TAMA, women (r)
- −0.214
- LAMA/BMI, men (r)
- 0.160
- LAMA/BMI, women (r)
- 0.119
- P was less than .001 for all
Original publication
Association Between Insulin Resistance and Myosteatosis Measured by Abdominal Computed Tomography. J Clin Endocrinol Metab. Published 4 July 2023. doi:10.
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