Gestational diabetes & diabetes in pregnancy
Association Between Glycemia, Glycemic Variability, and Pregnancy Complications in Early Gestational Diabetes Mellitus (GDM)
Authors' conclusion
Both early and delayed treatment of early GDM resulted in similar glycemia toward the end of pregnancy. Early treatment was associated with improved glycemia overall.
Study context
- Population
- Women with early GDM (2013 WHO criteria) in a trial of immediate vs delayed treatment; mean age 32.3 ± 4.9 years, BMI 32.0 ± 8.0 kg/m², 35% European, GDM diagnosed at 15.2 ± 2.4 weeksof 549 with blood glucose (BG) data
- Participants
- 329 women
- Comparison
- Early vs late treatment of early GDM
- Treated earlyn = 213
- Treated laten = 116reference
Methodological detailssubstudy
- Substudy
Primary result
As reported in the abstract
Glycemia (capillary BG, mmol/L)
- Mean glucose: Treated early 5.7 ± 0.4 vs Treated late 5.9 ± 0.5, P < 0.001
- Mean fasting glucose: Treated early 5.2 ± 0.3 vs Treated late 5.3 ± 0.4, P = 0.004
- Optimal glycemia (≥95% of BG 70-140 mg/dL): Treated early 74.6% vs Treated late 59.5%, P = 0.006
- Glycemic variability similar
Further findings
Mean glucose from 30 weeks' gestation
- Mean glucose (MG) was similar from 30 weeks' gestation
Optimal glycemia overall and pregnancy outcomes
- Optimal glycemia achieved overall
- 69%
- Large-for-gestational-age infants, optimal vs suboptimal glycemia
- 14.4% vs. 26.7%, P = 0.01
- Small-for-gestational-age infants, optimal vs suboptimal glycemia
- 15.3% vs. 5.9%, P = 0.02
- Gestational weight gain, optimal vs suboptimal glycemia
- 4.9 ± 6.4 vs. 7.6 ± 6.2 kg, P = 0.001
- Optimal glycemia associated with lower birth weight
Factors associated with suboptimal glycemia
- Suboptimal glycemia associated with non-European ethnicity, prior GDM, 1-h glucose at booking OGTT, and insulin use
Original publication
Association Between Glycemia, Glycemic Variability, and Pregnancy Complications in Early GDM. Diabetes Care. Published 12 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →