The association between glycated hemoglobin levels and long-term prognosis in patients with diabetes and triple-vessel coronary disease across different age groups: A cohort study
Authors' conclusion
Our study revealed variations in the relationship between HbA1c levels and endpoint events among patients with TVD and diabetes of different ages. In younger patients, elevated HbA1c levels were associated with a higher risk of death and MACCE, while in older patients, excessively low HbA1c levels (HbA1c < 6 %) were linked to a higher risk of death and MACCE.
Study context
- Population
- Patients with diabetes and triple-vessel coronary disease (TVD)
- Participants
- 2,051 patients
- Exposure
- HbA1c categories
- Outcome
- All-cause death
- Follow-up
- Median 5.88 years
Main finding
As reported in the abstract
All-cause deaths, total cohort
323
15.7 %
Observational data: associations, not effects.
Secondary outcomes
Major adverse cardiovascular and cerebrovascular events (MACCE) · median follow-up 5.88 years
- MACCEs, total cohort
- 537 (26.2 %)
Endpoint events by age subgroup
- Significant interaction between HbA1c and age
- Age < 70 years: risk of endpoint events gradually rose as HbA1c increased
- Age ≥70 years: L-shaped relationship, highest risk with HbA1c < 6.0 %
Original publication
The association between glycated hemoglobin levels and long-term prognosis in patients with diabetes and triple-vessel coronary disease across different age groups: A cohort study. Diabetes Res Clin Pract. Published 19 June 2024. doi:10.
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