Impact of oxidative stress on myocardial performance in patients with diabetes: a focus on subclinical left ventricular dysfunction
Authors' conclusion
Both oxidative stress and myocardial dysfunction were found to be more common in patients with DM. The study's findings indicated the negative effect of oxidative stress on myocardial functions. Accordingly, increased oxidative stress caused more significant deterioration in MPI in patients with DM compared with healthy individuals.
Study context
- Population
- Patients with and without diabetes mellitus (DM) evaluated for oxidative stress and SCLVD by tissue Doppler echocardiography
- Participants
- 151 patients
- Exposure
- Patients with DM vs healthy individuals
- DMn = 81
- Healthyn = 70reference
- Outcome
- Relationship between oxidative stress (total oxidant status (TOS), total antioxidant status (TAS), OSI) and SCLVD assessed by Myocardial Performance Index (MPI)
Methodological detailsobservational, single-centre
- Observational
- Single-centre
Main finding
As reported in the abstract
Correlation between OSI and MPI mitral
| Group | Value | p |
|---|---|---|
| DM | R 0.554 | p = <0.001 |
| Healthy | R −0.069 | p=0.249 |
Value
DMR 0.554
HealthyR −0.069
p
DMp = <0.001
Healthyp=0.249
Observational data: associations, not effects.
Further findings
| Outcome | DM | Healthy | P value |
|---|---|---|---|
| TOSHigher with DM | mean 5.72 ± 0.55 | mean 5.31 ± 0.50 | P = <0.001 |
| OSIHigher with DM | mean 4.92 ± 1.93 | mean 1.79 ± 0.39 | P = <0.001 |
| TASLower with DM | mean 1.21 ± 0.40 | mean 3.23 ± 0.51 | P = <0.001 |
Original publication
Impact of oxidative stress on myocardial performance in patients with diabetes: a focus on subclinical left ventricular dysfunction. BMJ Open Diabetes Res Care. Published 17 June 2024. doi:10.
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