Association between continued metformin use during hospital admission and hospital‐acquired complications
Main finding · HACResult — go to the resultAdjusted hazard ratio 0.85 95% CI 0.69–1.04Authors' conclusion
An individualized assessment to continue metformin during hospital admission was associated with a reduced likelihood of HAC, with the caveat that there was limited matching to non-diabetes controls. This finding warrants further exploration.
Study context
- Population
- Patients admitted to a medical or surgical ward; 4446 (14%) with diabetes, 3331 (10%) prescribed metformin on admission
- Exposure
- Continued metformin in hospital vs propensity score-matched (PSM) controls without diabetes
- DM/METn = 2,557
- Outcome
- Hospital-acquired complication (HAC)
Methodological detailspropensity score-matched control groups
- Propensity score-matched control groups
Main finding
HAC
Adjusted hazard ratio
0.85
95% CI 0.69–1.04
P = 0.117
By group
DM/METvs PSM control
aHR 0.85 (95% CI 0.69–1.04); P = 0.117
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | aHR (CI) | P value | |
|---|---|---|---|
| HAC, DM/NoMET and DM/MET-STOP vs respective PSM controlsDM/NoMETvs PSM controlvs its respective PSM control group | 1.77 (1.44–2.18) | P < 0.001 | |
| HAC, DM/NoMET and DM/MET-STOP vs respective PSM controlsDM/MET-STOPvs PSM controlvs its respective PSM control group | 2.57 (2.10–3.13) | P < 0.001 | |
| 0.20.5125Adjusted hazard ratio (log scale) |
Original publication
Association between continued metformin use during hospital admission and hospital‐acquired complications. Diabet Med. Published 31 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →