Initiating GLP-1 Therapy in Combination with FreeStyle Libre Provides Greater Benefit Compared with GLP-1 Therapy Alone
Authors' conclusion
Adults with suboptimally controlled T2D, initiating GLP-1 RA with FreeStyle Libre, had greater improvement in HbA1c compared with those treated with GLP-1 RA only.
Study context
- Population
- Adults with T2D and hemoglobin A1c (HbA1c) ≥8% who acquired their first GLP-1 RA between 2018 and 2022, Optum's de-identified Market Clarity Dataunmatched cohort
- Participants
- 24,724 adults
- Exposure
- GLP-1 RA with FreeStyle Libre vs GLP-1 RA without FreeStyle Libre
- GLP-1+FSLn = 478
- GLP-1n = 24,246reference
- Outcome
- Paired change in HbA1c
- Follow-up
- 6 months
Methodological detailsreal-world, linked electronic health records (EHR)-claims database, matched 1:5 on baseline insulin therapy, age, sex, baseline HbA1c and GLP-1 type
- Real-world
- Linked EHR-claims database
- Matched 1:5 on baseline insulin therapy, age, sex, baseline HbA1c and GLP-1 type
Main finding
Change in HbA1c, matched cohort
Difference
0.37 %
P < 0.001
Change by group
GLP-1+FSL
−2.43
%
GLP-1
−2.06
%
As reported in the abstract
Observational data: associations, not effects.
Further findings
%
| Outcome | GLP-1+FSL | GLP-1 | Difference (%) | P value |
|---|---|---|---|---|
| Change in HbA1c, unmatched cohort · 6 monthsGreater HbA1c reduction with GLP-1+FSL | −2.43 | −1.73 | 0.70 | P < 0.001 |
Change in HbA1c, subgroups (GLP-1+FSL vs GLP-1)
- Intensive insulin
- −2.32% vs. −1.50%
- Nonintensive insulin
- −2.50% vs. −1.74%
- Noninsulin
- −2.46% vs. −1.78%
- Semaglutide
- −2.73% vs. −1.92%
- Dulaglutide
- −2.45% vs. −1.71%
- All P < 0.001
Original publication
Initiating GLP-1 Therapy in Combination with FreeStyle Libre Provides Greater Benefit Compared with GLP-1 Therapy Alone. Diabetes Technol Ther. Published 31 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →