Association between Chinese visceral adiposity index and heart failure in diabetic patients
Authors' conclusion
CVAI is independently associated with HF risk, especially in elderly patients, supporting its utility for visceral fat-related risk stratification.
Study context
- Population
- Patients with diabetes, Kailuan Study, 2006–2022
- Participants
- 12,243 patients
- Exposure
- Chinese visceral adiposity index (CVAI) quartiles Q2–Q4 vs Q1
- Q1n = 3,060reference
- Q2n = 3,061
- Q3n = 3,061
- Q4n = 3,061
- Outcome
- Incident HF
- Follow-up
- Median 15 years
Methodological detailsKailuan Study
- Kailuan Study
Main finding
As reported in the abstract
HF
Each group vs Q1Adjusted hazard ratio (95% CI)P value
Q2
1.32(1.06–1.65)
P < 0.01for trendQ3
1.41(1.13–1.75)
P < 0.01for trendQ4
1.91(1.55–2.35)
P < 0.01for trend- New heart failure (HF) cases
- 861
- HF incidence rose with increasing CVAI quartiles (Q1-Q4), p < 0.05
- 3.05-7.20/1000 person-years
Observational data: associations, not effects.
Further findings
Effect modification by age (≥60 years)
- HR in ≥60 years
- 2.06 (95% CI 1.60-2.64; Pinteraction <0.01)
Shape of CVAI–HF association
- Linear correlation (Pnonlinear = 0.75)
Predictive accuracy (ROC) vs other obesity indices
- CVAI superior ROC-predictive accuracy vs other indices (p < 0.01)
Original publication
Association between Chinese visceral adiposity index and heart failure in diabetic patients. Diabetes Obes Metab. Published 22 August 2025. doi:10.
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