Association between atherogenic index of plasma with all-cause and cardiovascular mortality in individuals with Cardiovascular-Kidney-Metabolic syndrome
Authors' conclusion
This study demonstrated that elevated AIP levels in individuals with CKM syndrome are strongly linked to higher mortality risks, notably all-cause mortality in advanced stages and CVD mortality across both non-advanced and advanced stages. These findings further highlight the importance of AIP as a valuable risk biomarker, providing a simple and effective tool for identifying mortality risk in individuals with CKM syndrome.
Study context
- Population
- Individuals with cardiovascular-Kidney-Metabolic (CKM) syndrome, National Health and Nutrition Examination Survey (NHANES) 2005–2018
- Participants
- 15,703 individuals
- Exposure
- Highest vs lowest atherogenic index of plasma (AIP) tertile
- Outcome
- All-cause and CVD mortality
- Follow-up
- Median 7.67 years
Methodological detailsNHANES 2005–2018, linked to National Death Index
- NHANES 2005–2018
- Linked to National Death Index
Main finding
As reported in the abstract
Highest AIP tertile vs Lowest AIP tertileHazard ratio (95% CI)P value
All-cause mortality; adjusted for covariates
1.19(1.08–1.31)
P < 0.001CVD mortality; adjusted for covariates
1.38(1.22–1.57)
P < 0.001- Deaths
- 1570
- Cardiovascular deaths
- 344
Observational data: associations, not effects.
Further findings
AIP as continuous variable
- Approximate positive linear dose-response relationship with all-cause and cardiovascular disease (CVD) mortality
Subgroup analysis
- No significant interactions with examined variables, except for gender
Original publication
Association between atherogenic index of plasma with all-cause and cardiovascular mortality in individuals with Cardiovascular-Kidney-Metabolic syndrome. Cardiovasc Diabetol. Published 26 April 2025. doi:10.
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