Lipids & metabolic liver disease
Dyslipidemia and aging: the non-linear association between atherogenic index of plasma (AIP) and aging acceleration
Authors' conclusion
An elevated AIP was notably and positively correlated with accelerated aging
Study context
- Population
- US adults aged over 20 years from National Health and Nutrition Examination Survey (NHANES)
- Participants
- 4,471 adults
- Exposure
- Association between AIP and PhenoAgeAccel
- Outcome
- Biological aging assessed by phenotypic age acceleration (PhenoAgeAccel)
Methodological detailsNHANES database, multivariable linear regression, restricted cubic spline, mediation analysis, network pharmacology
- NHANES database
- Multivariable linear regression
- Restricted cubic spline
- Mediation analysis
- Network pharmacology
Main finding
As reported in the abstract
PhenoAgeAccel per one unit increase of AIP
β per one unit increase of AIP, fully adjusted model
1.820
95% CI 1.085–2.556
Observational data: associations, not effects.
Further findings
Nonlinear relationship between AIP and PhenoAgeAccel (restricted cubic spline (RCS); threshold and saturation effect analysis)
- Inflection point for AIP
- −0.043
- β before inflection point
- 6.550 (95% CI: 5.070-8.030)
- β after inflection point
- 3.898 (95% CI: 2.474-5.322)
Mediation by homeostatic model assessment of insulin resistance (HOMA-IR) of the AIP–PhenoAgeAccel association
- Proportion mediated by HOMA-IR
- 39.21%
Overall population characteristics (median)
- Chronological age, years
- 49 (35-64)
- PhenoAge, years
- 42.85 (27.30-59.68)
- PhenoAgeAccel, years
- - 6.92 (- 10.52 to −2.46)
Network pharmacology
- Core targets INS, APOE, APOB, IL6, IL10, PPARG, MTOR, ACE, PPARGC1A and SERPINE1, linked to AMPK, apelin, JAK-STAT, FoxO pathways
Original publication
Dyslipidemia and aging: the non-linear association between atherogenic index of plasma (AIP) and aging acceleration. Cardiovasc Diabetol. Published 25 April 2025. doi:10.
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