Association between adipose deposition and mortality among adults without major cardiovascular risk factors
Authors' conclusion
Imaging-based adiposity measures have distinct prognostic value for mortality beyond traditional anthropometrics in adults without cardiovascular risk factors.
Study context
- Population
- U.S. adults aged >20 years without CVD, eGFR <60 ml/min/1.73m², diabetes, hypertension or pregnancy
- Participants
- 7,948 adults
- Exposure
- Adiposity measures in relation to all-cause mortality
- Womenn = 4,123
- Menn = 3,825
- Outcome
- All-cause mortality
- Follow-up
- Median 7.8 years
Methodological detailsNational Health and Nutrition Examination Survey (2003-2004, 2011-2016), multivariable-adjusted Cox regression, restricted cubic spline models, sex-specific analyses
- National Health and Nutrition Examination Survey (2003-2004, 2011-2016)
- Multivariable-adjusted Cox regression
- Restricted cubic spline models
- Sex-specific analyses
Main finding
As reported in the abstract
All-cause mortality per 1-SD increase in FMI (final adjusted models)
Women
83
events
Men
119
events
Hazard ratio (95 % CI)
Women: visceral FMI per 1-SD
1.61(1.17–2.21)
Women: subcutaneous FMI per 1-SD
1.87(1.13–3.08)
Women: abdominal FMI per 1-SD
1.89(1.19–2.99)
Women: lowest tertile of gynoid FMIvs middle tertile
1.82(1.01–3.29)
Men: gynoid FMI per 1-SD
1.30(1.02–1.65)
Men: android FMI per 1-SD
1.41(1.09–1.83)
Men: visceral FMI per 1-SD
1.54(1.04–2.28)
Men: subcutaneous FMI per 1-SD
1.69(1.25–2.29)
Men: abdominal FMI per 1-SD
1.76(1.25–2.48)
- Men, middle vs lowest tertile of android-to-gynoid ratio: higher mortality risk
- 2.68-fold
- Men, highest vs lowest BMI tertile: higher mortality risk
- 83 %
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Effect modification by sex of gynoid FMI–mortality association | P for interaction = 0.008 |
Original publication
Association between adipose deposition and mortality among adults without major cardiovascular risk factors. Diabetes Metab. Published 28 November 2024. doi:10.
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