Assessment of neuropathy subtypes in type 1 diabetes
Authors' conclusion
DPN primarily manifests as MFN in T1DM, with no differentiation between NP-DPN and P-DPN. Additionally, we propose model 2 as an initial criterion for diagnosing DPN with a more prevalent SFN subtype in T1DM. Lastly, the study suggests that in mild stages of DPN, one type of nerve fiber (either small or large) is more susceptible to damage.
Study context
- Population
- Controls and people with T1D with or without diabetic polyneuropathy (DPN) (painful or non-painful); DPN subgrouped by neuropathy severity
- Participants
- 216 controls
- Exposure
- Prevalence of SFN, LFN and MFN in T1D-associated DPN, with and without pain
- Outcome
- More prevalent type of nerve fiber damage (SFN, LFN, MFN) in T1D-associated DPN, by small and large fiber-specific tests and three diagnostic models (≥1, ≥2, ≥3 abnormal tests)
Main finding
As reported in the abstract
Neuropathy subtype prevalence in T1D-associated DPN
- MFN showed the highest prevalence in T1D-associated DPN
- No differences in neuropathy subtype between non-painful DPN (NP-DPN) and painful DPN (P-DPN)
Observational data: associations, not effects.
Further findings
Subtype by diagnostic model and DPN severity
- DPN with prevalent SFN plateaus between models 2 and 3
- All models showed increased MFN prevalence with DPN severity
- Model 3 showed increased DPN with prevalent LFN in early neuropathy; DPN with prevalent SFN showed a similar, non-significant pattern
Original publication
Assessment of neuropathy subtypes in type 1 diabetes. BMJ Open Diabetes Res Care. Published 18 July 2024. doi:10.
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