Assessment of the Impact of Subcutaneous Catheter Change on Glucose Control in Patients with Type 1 Diabetes Treated by Insulin Pump in Open- and Closed-Loop Modes
Authors' conclusion
This study shows an increase in time spent in hyperglycemia on the day of the KT change both in OL and AID modes.
Study context
- Population
- Patients with T1D using Tandem t:slim x2 pump and Dexcom G6 sensor for 20 days in open-loop (OL), then as automated insulin delivery (AID); 72 women (54%), age 35.6 ± 15.7 years, body mass index (BMI) 25.2 ± 4.7 kg/m², hemoglobin A1c (HbA1c) 7.5 ± 0.8%1,636 KT changes
- Participants
- 134 patients
- Exposure
- %TAR180 on day of catheter change (D0) vs next day (D1) and 2 days later (D2), in OL and AID modes
- Outcome
- Percentage of time with sensor glucose >180 mg/dL (%TAR180)
Methodological detailsadjusted for age, gender, BMI, HbA1c at inclusion and %TAR180 for the 2 h before KT change
- Adjusted for age, gender, BMI, HbA1c at inclusion and %TAR180 for the 2 h before KT change
Main finding
As reported in the abstract
%TAR180
- D0 vs D1 · OL mode
- absolute increase +6.9 %; P < 0.0001
- D0 vs D2 · OL mode
- absolute increase +6.8 %; P < 0.0001
- D0 vs D1 · AID mode
- absolute increase +4.8 %; P < 0.0001
- D0 vs D2 · AID mode
- absolute increase +4.2 %; P < 0.0001
Observational data: associations, not effects.
Further findings
%TAR180 in the 2 h before KT change
- OL mode
- 51.3 ± 37.0%
- AID mode
- 33.2 ± 30.0%
Original publication
Assessment of the Impact of Subcutaneous Catheter Change on Glucose Control in Patients with Type 1 Diabetes Treated by Insulin Pump in Open- and Closed-Loop Modes. Diabetes Technol Ther. Published 7 March 2024. doi:10.
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