Antigen-Presenting Cell Isolevuglandins Link Salt Sensitivity of Blood Pressure to Insulin Resistance
Authors' conclusion
Within 24 hours of acute salt depletion, markers of insulin resistance exhibit a significant increase, which strongly correlates with change in IsoLG formation in APCs. This finding implies that oxidative stress in APCs may be implicated in the salt-sensitive modulation of glucose metabolism.
Study context
- Population
- Participants with hypertension
- Participants
- 20 participants
- Comparison
- Acute salt loading vs salt depletion
- Outcome
- Insulin resistance (HOMA-IR) and IsoLG + APCs
- Follow-up
- 24 hours
Methodological detailsinpatient protocol of salt loading and depletion
- Inpatient protocol of salt loading and depletion
Main finding
As reported in the abstract
24 hours
- Baseline insulin resistance correlated with higher salt sensitivity
- Insulin resistance significantly increased from salt loading to salt depletion
- Salt depletion induced changes in isolevuglandin (IsoLG) + antigen-presenting cells (APCs) significantly correlated with changes in HOMA-IR
- Correlation significant only in participants insulin resistant at baseline
Original publication
Antigen-Presenting Cell Isolevuglandins Link Salt Sensitivity of Blood Pressure to Insulin Resistance. J Clin Endocrinol Metab. Published 7 October 2025. doi:10.
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