Altered proteome profiles related to visceral adiposity may mediate the favorable effect of green Mediterranean diet: the DIRECT‐PLUS trial
Authors' conclusion
Proteomics clusters may enhance our understanding of the favorable effect of a green-MED diet that is enriched with polyphenols and low in red/processed meat on visceral adiposity and cardiometabolic risk.
Study context
- Population
- Participants with abdominal obesity
- Participants
- 294 participants
- Comparison
- Green-MED diet vs Mediterranean (MED) diet vs healthy dietary guidelines
Methodological details18-month weight loss trial, proteomics (Olink CVDII) at three time points
- 18-month weight loss trial
- Proteomics (Olink CVDII) at three time points
Primary result
As reported in the abstract
6 months
- Green-MED led to more pronounced beneficial changes, largely driven by proinflammatory proteins (IL-1 receptor antagonist protein, IL-16, IL-18, thrombospondin-2, leptin, prostasin, galectin-9, FGF21); adjusted for age, sex and weight loss; p < 0.05
- MED vs Healthy dietary guidelines: P < 0.05
- Green-MED vs Healthy dietary guidelines: P < 0.05
Further findings
Baseline protein cluster and cardiometabolic risk
- Dominant protein cluster significantly related to higher cardiometabolic risk parameters, strongest with MRI-assessed visceral adiposity (false discovery rate of 5%)
Proteomics cluster changes and visceral adiposity · 18 months
- Proteomics cluster changes showed the strongest correlations with visceral adiposity reduction
Original publication
Altered proteome profiles related to visceral adiposity may mediate the favorable effect of green Mediterranean diet: the DIRECT‐PLUS trial. Obesity (Silver Spring). Published 16 May 2024. doi:10.
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