Altered extracellular matrix dynamics is associated with insulin resistance in adolescent children with obesity
Authors' conclusion
Altered extracellular matrix dynamics, but not expandability, potentially decreases abdominal SAT lipid storage capacity, contributing to the pathophysiological pathways linking adipose tissue and whole-body IR with altered ectopic storage of lipids within the liver among IR adolescents with obesity.
Study context
- Population
- Adolescents with obesity; 3-h OGTT, abdominal MRI, abdominal and gluteal fat biopsies
- Participants
- 7 vs 7
- Comparison
- Insulin-resistant vs insulin-sensitive adolescents with obesity
- Insulin-resistant (IR)n = 7
- Insulin-sensitive (IS)n = 7reference
- Outcome
- Adipocyte turnover, lipid dynamics and fibrogenesis in abdominal and gluteal SAT
- Follow-up
- 8 weeks
Methodological detailsin vivo 2H2O labeling, 8-week labeling protocol
- In vivo 2H2O labeling
- 8-week labeling protocol
Main finding
As reported in the abstract
- Abdominal and gluteal subcutaneous adipose tissue (SAT) turnover rates of lipid components similar in IS and IR
- Abdominal (not gluteal) SAT insoluble collagen Iα2 elevated in IR vs IS
Further findings
Associations of abdominal insoluble collagen Iα2
- Associated with visceral-to-total abdominal fat ratio and whole-body and adipose tissue insulin signaling
- Trend toward positive association with liver fat content
Original publication
Altered extracellular matrix dynamics is associated with insulin resistance in adolescent children with obesity. Obesity (Silver Spring). Published 27 February 2024. doi:10.
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