Altered Emotion Perception Linked to Structural Brain Differences in Youth With Congenital Adrenal Hyperplasia
Authors' conclusion
Findings suggest that youth with CAH perceive emotive stimuli as more unpleasant. Decreased brain volumes in the amygdala, hippocampus, and prefrontal cortex are associated with these measures of altered emotion perception in youth with CAH.
Study context
- Population
- Youth with congenital adrenal hyperplasia and age- and sex-matched controls; ratings of 61 affective images and 3T structural MRI
- Participants
- 27 vs 35
- Exposure
- Youth with congenital adrenal hyperplasia (CAH) vs controls
- CAHn = 27
- Controlsn = 35reference
- Outcome
- Valence ratings of affective images
Methodological detailsage- and sex-matched controls
- Age- and sex-matched controls
Main finding
As reported in the abstract
- CAH vs Controls: P = 0.007
- CAH vs Controls: P = 0.019
Observational data: associations, not effects.
Further findings
Reaction times and arousal ratings across stimuli conditions
- Controls showed differences in reaction times and arousal ratings across stimuli conditions; youth with CAH did not
Brain volumes associated with valence ratings
- Right amygdala volume associated with valence ratings
- P = 0.025
- Left hippocampus volume associated with valence ratings
- P = 0.002
- Left rostral middle frontal volume negatively related to valence scores only in CAH
- P < 0.001
- Right medial orbitofrontal cortex volume negatively related to valence scores only in CAH
- P = 0.002
- Left medial orbitofrontal cortex volume associated with valence positively in CAH and negatively in controls
- P < 0.001
Original publication
Altered Emotion Perception Linked to Structural Brain Differences in Youth With Congenital Adrenal Hyperplasia. J Clin Endocrinol Metab. Published 17 March 2023. doi:10.
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