Alterations in gene expression associated with invasion of RAS-mutant thyroid tumors and their potential diagnostic and therapeutic utility
Authors' conclusion
Development of invasion in RAS-mutant tumors is associated with significant alteration in gene expression. Expression levels of six genes and nodule size may predict invasion in RAS-mutant thyroid nodules, whereas chemical inhibition of CA12 may have a potential therapeutic effect in RAS-mutant tumors.
Study context
- Population
- Surgically resected RAS-mutant thyroid tumours; independent set of RAS-mutant fine-needle aspiration (FNA) samplesplus 54 FNA samples
- Participants
- 48 participants
- Comparison
- Invasive vs non-invasive RAS-mutant thyroid tumours
- Invasiven = 25
- Non-invasiven = 23reference
- Outcome
- Prediction of invasion in RAS-mutant FNA samples (6-gene expression plus nodule size)
Methodological detailsRNA-seq, independent FNA validation set, in vitro and in vivo experiments
- RNA-seq
- Independent FNA validation set
- In vitro and in vivo experiments
Main finding
As reported in the abstract
Sensitivity of classifier (6 genes + nodule size) for invasion in FNA samples
95%
Specificity of classifier (6 genes + nodule size) for invasion in FNA samples
89%
Original publication
Alterations in gene expression associated with invasion of RAS-mutant thyroid tumors and their potential diagnostic and therapeutic utility. Eur Thyroid J. Published 29 May 2025. doi:10.
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