Aiming for the Best Glycemic Control Beyond Time in Range: Time in Tight Range as a New Continuous Glucose Monitoring Metric in Children and Adolescents with Type 1 Diabetes Using Different Treatment Modalities
Authors' conclusion
Our study highlights that most children and adolescents with type 1 diabetes present TITR levels below 50%, except those using HCL.
Study context
- Population
- Children and adolescents with T1D, consecutively recruited, 2 centres
- Participants
- 854 children
- Exposure
- Four treatment modalities: MDI + rtCGM, MDI + isCGM, sensor augmented pump, HCL
- Outcome
- Time in tight range (TITR) 70-140 mg/dL (3.9-7.8 mmol/L)
Methodological detailsreal world, dual center, consecutive recruitment
- Real world
- Dual center
- Consecutive recruitment
Main finding
As reported in the abstract
TITR
Average time in tight range (TITR), overall population
36.4% ± 12.8%
Observational data: associations, not effects.
Further findings
Time in range (TIR) cut-off identifying TITR ≥50%
- TIR cut-off value
- 71.9%
- AUC
- 0.98 (95% CI 0.97-0.99, P < 0.001)
- Correlation TIR–TITR (P < 0.001)
- r = 0.95
Likelihood of TITR ≥50% per 1% increase in TIR
- Increased likelihood per 1% TIR increase (R2 Nagelkerke = 0.35, P < 0.001)
- 1.84
Predictors of TITR levels
- Use of HCL systems (P < 0.001)
- B = 7.78
- Disease duration (P = 0.006)
- B = −0.26
- CV (P = 0.004)
- B = −0.30
- HbA1c (P < 0.001)
- B = −8.82
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Aiming for the Best Glycemic Control Beyond Time in Range: Time in Tight Range as a New Continuous Glucose Monitoring Metric in Children and Adolescents with Type 1 Diabetes Using Different Treatment Modalities. Diabetes Technol Ther. Published 1 February 2024. doi:10.
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