Agreement Between HbA1C and Continuous Glucose Monitoring–Derived Glycemic Metrics in Adults With Cystic Fibrosis Related Diabetes
Authors' conclusion
These findings indicate that HbA1C closely reflects CGM-derived mean glycemia in adults with established CFRD.
Study context
- Population
- Adults with confirmed CF-related diabetes with laboratory HbA1c paired with ≥30 days of CGM data (≥70% active sensor time) in the preceding 30–90 days; anemia, advanced CKD and pregnancy excluded; mean age 43.9 years, 69.4% male
- Participants
- 49 adults
- Exposure
- HbA1c vs CGM-derived glycemic metrics
- Outcome
- Agreement of HbA1c with CGM-derived mean glycemia
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- Mean HbA1c
- 7.3% ± 1.1% (56 ± 12 mmol/mol)
- Mean Glucose Management Indicator (GMI)
- 7.6% ± 1.0% (60 ± 11 mmol/mol)
- Mean sensor glucose
- 178.6 ± 40.3 mg/dL (9.9 ± 2.2 mmol/L)
- Correlation HbA1c with GMI
- r = 0.90; P< .0001
- Correlation HbA1c with mean sensor glucose
- r = 0.90; P< .0001
- Bland-Altman mean bias (GMI-HbA1c)
- +0.30%
- 95% limits of agreement
- −0.65% to +1.25%
Observational data: associations, not effects.
Further findings
CGM adherence
- Median sensor active time
- 97%
Original publication
Agreement Between HbA1C and Continuous Glucose Monitoring–Derived Glycemic Metrics in Adults With Cystic Fibrosis Related Diabetes. Endocr Pract. Published 20 April 2026. doi:10.
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