Age-Stratified Reference Ranges for Directly Measured Serum Free Testosterone in Community-Dwelling and Healthy Men
Authors' conclusion
This study provides age-stratified reference ranges for mFT in adult men, established in the largest cohort to date, using published methodology. Our results also show that mFT levels are influenced by age and BMI. Future work should focus on whether age-stratified or reference ranges for young men should be employed, and how mFT can best be implemented in clinical practice including the improved application of calculated FT.
Study context
- Population
- Healthy and community-dwelling adult White men from large population cohort studies
- Participants
- 1,202 participants
- Outcome
- Age-stratified reference ranges (2.5th–97.5th percentiles) for mFT measured by equilibrium dialysis and LC-MS/MS
Methodological detailsreference range study, population cohorts, CLSI guidelines
- Reference range study
- Population cohorts
- CLSI guidelines
Main finding
As reported in the abstract
Reference range (2.5th–97.5th percentiles)
184 to 749 pmol/L
Observational data: associations, not effects.
Further findings
Measured FT (mFT) change with age
- Decrease in mFT per year of age
- −4.5 pmol/L
mFT by body mass index (BMI) vs reference BMI of 22
- Decrease in mFT with BMI 30
- 14.4%
- Decrease in mFT with BMI 35
- 22.2%
Original publication
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