Age‐Independent Serum Anti-Müllerian Hormone (AMH) Levels in Women With PCOS Defined by the 2018 Evidence‐Based Guideline Diagnostic Criteria: A Cross‐Sectional Study
Authors' conclusion
Women who continued to meet the stricter criteria at older reproductive ages showed AMH levels comparable to those of younger patients, and had worse metabolic profiles, supporting AMH as a stable diagnostic marker across reproductive ages in PCOS.
Study context
- Population
- Women with PCOS by Rotterdam criteria, a subset also fulfilling the stricter 2018 evidence-based guideline criteria (follicle count threshold ≥ 20)520 met 2018 criteria
- Participants
- 725 women
- Exposure
- Serum AMH across age groups in women with PCOS
- Outcome
- Serum AMH levels across age groups
Main finding
As reported in the abstract
Serum AMH, women meeting 2018 criteria
P = 0.077
- Correlation between age and AMH (no correlation)
- r = −0.050, p = 0.178
Observational data: associations, not effects.
Further findings
ng/mL
| Outcome | < 25 | 35-45 | P value |
|---|---|---|---|
| Serum AMH, women meeting Rotterdam criteria35-45 vs < 25 · significantly lower in the oldest group | 11.2 | 9.0 | P = 0.032 |
Metabolic profiles
- Oldest group showed worse metabolic profiles than the younger groups
Original publication
Age‐Independent Serum AMH Levels in Women With PCOS Defined by the 2018 Evidence‐Based Guideline Diagnostic Criteria: A Cross‐Sectional Study. Clin Endocrinol (Oxf). Published 9 July 2025. doi:10.
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