Age and hematologic parameters can predict prolonged glucocorticoid replacement after remission of cushing disease and adrenal Cushing’s syndrome: A nationwide cohort study
Authors' conclusion
Older age, and lower baseline neutrophils and NLR, were associated with prolonged postoperative GC replacement.
Study context
- Population
- Patients with endogenous Cushing’s syndrome (CS) (Cushing disease (CD) or adrenal CS) after curative pituitary or adrenal surgery, Clalit Health Services, Israel, 2000–2023; adrenal carcinoma or ectopic CS excluded; mean age 43.8 ± 13.7 years, 76.7% women41 CD, 56 adrenal CS
- Participants
- 103 patients
- Exposure
- Glucocorticoid (GC) replacement ≥ 20 months vs < 20 months
- ≥ 20 monthsn = 51
- Outcome
- Clinical and hematologic predictors of GC replacement duration (< 20 vs ≥ 20 months)
Methodological detailsnationwide
- Nationwide
Main finding
As reported in the abstract
Predictors of prolonged GC replacement (≥ 20 months)
≥ 20 months
49.5%
51
≥ 20 months vs < 20 months: P = 0.0045 · ≥ 20 months vs < 20 months: P = 0.050 · ≥ 20 months vs < 20 months: P = 0.026
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Overall survivalLower survival with prolonged therapy | P = 0.045 |
GC formulation
- Hydrocortisone associated with longer GC replacement than prednisone
Overall survival
- Overall survival did not differ by GC duration
Original publication
Age and hematologic parameters can predict prolonged glucocorticoid replacement after remission of cushing disease and adrenal Cushing’s syndrome: A nationwide cohort study. Pituitary. Published 25 March 2026. doi:10.
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