Age‐dependent changes in the prognostic advantage of papillary thyroid cancer in women: A SEER‐based study
Authors' conclusion
The overall PTC prognosis of women is better than that of men, but the prognostic advantage of women diminishes with age and tumour growth. These differences in prognosis may be due to some indirect factors caused by different sexes.
Study context
- Population
- Patients with papillary thyroid cancer (PTC) (SEER)
- Participants
- 108,459 patients
- Exposure
- Women vs men
- Outcome
- Disease specific survival (DSS) by sex
Methodological detailsSEER-based, inverse probability of treatment weighting (IPTW), restricted cubic splines, multiple mediation analyses
- SEER-based
- Inverse probability of treatment weighting (IPTW)
- Restricted cubic splines
- Multiple mediation analyses
Main finding
As reported in the abstract
DSS
Women vs MenHazard ratio (CI)
IPTW-adjusted
0.67(0.60–0.76)
- Disease specific survival (DSS)
- χ2 458.57; P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | P value | |
|---|---|---|---|
| DSS across age intervals (subgroup analysis)Womenvs Men | crude HR 0.166 (CI 0.082–0.337) | P < 0.001 | |
| DSS across age intervals (subgroup analysis)Womenvs Men | IPTW-adjusted HR 0.331 (CI 0.161–0.681) | P < 0.001 | |
| 0.050.21520Ratio (log scale) |
DSS across age intervals (subgroup analysis)
- Difference between sexes gradually narrowed with increasing age
DSS by tumour type (papillary thyroid microcarcinoma (PTMC) vs PTC)
- Prognosis of women better than men in PTMC; advantage not obvious in PTC
Original publication
Age‐dependent changes in the prognostic advantage of papillary thyroid cancer in women: A SEER‐based study. Clin Endocrinol (Oxf). Published 24 February 2023. doi:10.
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