Prior Thyroid and Nonthyroid Cancer History Do Not Significantly Alter Overall Survival in Patients Diagnosed with Anaplastic Thyroid Cancer
Authors' conclusion
The presence of prior malignancy does not significantly impact OS in patients with ATC.
Study context
- Population
- Patients with anaplastic thyroid cancer (ATC) treated at MD Anderson between 2000 and 2019
- Participants
- 451 patients
- Exposure
- Prior or concomitant malignancy vs none
- Prior differentiated thyroid cancer (DTC)n = 62
- Concomitant DTCn = 234
- Prior nonthyroid cancern = 102
- Outcome
- OS
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
OS (multivariate analysis adjusted for age and overall stage)
- Prior DTC, concomitant DTC and prior nonthyroid cancers all had no significant impact on overall survival (OS)
Observational data: associations, not effects.
Further findings
Prevalence of prior and concomitant cancers
Median, years
| Outcome | Prior DTC | Concomitant DTC | Prior nonthyroid cancer |
|---|---|---|---|
| Time from prior cancer diagnosis to ATC diagnosis | 3.5 (range 6 months to 35 years) | — not stated in the abstract | 8 (range 3 months to 53 years) |
— not stated in the abstract
- Prevalence of prior and concomitant cancers — Prior DTC that was papillary thyroid cancer
- 81%, n = 50
- Prevalence of prior and concomitant cancers — One / two / three prior nonthyroid cancers
- 19% (n = 87) / 2% (n = 10) / 1% (n = 5)
- Prevalence of prior and concomitant cancers — Most common prior nonthyroid cancers: nonmelanoma skin / prostate / breast
- 28.4% / 19.6% / 16.7%
Tumor driver mutations (BRAF, RAS, TP53), subgroup with mutation information (n = 183)
- Frequency not significantly different between ATC with and without history of nonthyroid cancer
Original publication
Prior Thyroid and Nonthyroid Cancer History Do Not Significantly Alter Overall Survival in Patients Diagnosed with Anaplastic Thyroid Cancer. Thyroid. Published 20 February 2023. doi:10.
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