Age at Type 2 Diabetes Diagnosis and Cause-Specific Mortality: Observational Study of Primary Care Patients in England
Authors' conclusion
Although the relative risk of death in individuals with versus without type 2 was higher at younger ages, the 10-year absolute risk of all investigated causes of death was small and similar in the two groups. Further multidecade studies could help estimate the long-term risk of complications and death in individuals with early-onset type 2 diabetes.
Study context
- Population
- Individuals with newly diagnosed T2D aged 16–50 years and matched individuals without T2D, primary care, Englandmatched cohort
- Participants
- 108,061 vs 829,946
- Exposure
- T2D vs no T2D, by age at diagnosis
- T2Dn = 108,061
- No T2Dn = 829,946reference
- Outcome
- All-cause and cause-specific mortality (cancer, cardiorenal, other [noncancer or cardiorenal]) by age at diagnosis
Methodological detailsprimary care data (Clinical Practice Research Datalink), competing-risk survival analyses adjusted for key confounders
- Primary care data (Clinical Practice Research Datalink)
- Competing-risk survival analyses adjusted for key confounders
Main finding
As reported in the abstract
All-cause mortality by age at diagnosis
T2D vs No T2DHazard ratio (95% CI)
Diagnosed at ages 16-27 years
4.32(3.35–5.58)
Diagnosed at ages 48-50 years
1.53(1.46–1.60)
Observational data: associations, not effects.
Further findings
Cancer, cardiorenal, and noncancer or cardiorenal death
- Smaller relative risks with increasing age at diagnosis
10-year absolute risk of all-cause and cause-specific mortality
- Higher with T2D irrespective of age at diagnosis; absolute differences small
Original publication
Age at Type 2 Diabetes Diagnosis and Cause-Specific Mortality: Observational Study of Primary Care Patients in England. Diabetes Care. Published 25 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →