Age at diabetes diagnosis and fracture risk in women: a cohort study from the Australian Longitudinal Study on Women’s Health
Authors' conclusion
Diabetes is associated with increased fracture risk, but this risk varies by age at diagnosis. Women diagnosed at younger ages face substantially higher risk, while those diagnosed later show little excess risk.
Study context
- Population
- Women of the 1946–1951 cohort of the Australian Longitudinal Study on Women's Health, followed from age 27 to 76 years3,761 (30.9%) with ≥1 fracture
- Participants
- 12,170 women
- Exposure
- Women with diabetes vs women without diabetes, by age at diabetes diagnosis
- Diabetesn = 2,251
- Outcome
- Fracture rate; modification of the diabetes–fracture association by age at diabetes diagnosis
Methodological detailslinked administrative health records, Poisson regression adjusted for age and time-varying BMI, stratified by age at diagnosis
- Linked administrative health records
- Poisson regression adjusted for age and time-varying BMI
- Stratified by age at diagnosis
Main finding
As reported in the abstract
Fracture risk by age at diabetes diagnosis
Relative risk (95% CI)
Diagnosis at age 35
1.61(1.23–2.12)
Diagnosis at age 60
1.02(0.90–1.16)
Observational data: associations, not effects.
Further findings
| Outcome | RR (95% CI) | |
|---|---|---|
| Fracture risk, diabetes overall | 1.13 (1.02–1.24) | |
| 0.512Relative risk (log scale) |
Original publication
Age at diabetes diagnosis and fracture risk in women: a cohort study from the Australian Longitudinal Study on Women’s Health. Osteoporos Int. Published 12 October 2025. doi:10.
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