Daily life stress is linked to increased glucose levels in individuals with insulin resistance: a real-world assessment
Authors' conclusion
Daily life stress contributes to a significant increase in glucose levels in IR individuals, highlighting the need for tailored interventions to mitigate further deterioration and potential progression to type 2 diabetes. These results underscore the importance of integrating stress management strategies into diabetes prevention in at-risk populations. Ambulatory assessments can serve as monitoring tools for identifying at-risk individuals and for testing the efficacy of targeted interventions.
Study context
- Population
- Participants aged 18–78 years; daily life stress and affect assessed for 3 days, CGM for 7 days
- Participants
- 116 participants
- Exposure
- Insulin-resistant vs insulin-sensitive participants
- IRn = 62
- ISn = 54reference
- Outcome
- Effect of daily life stress on glucose levels
Methodological detailscontinuous glucose monitoring, linear mixed-effect models
- Continuous glucose monitoring
- Linear mixed-effect models
Main finding
As reported in the abstract
Effect of stress on blood glucose level
| Group | Value | p |
|---|---|---|
| IR | β ^ 6.24 × 10 - 3 | p=0.005 |
IR
Valueβ ^ 6.24 × 10 - 3
pp=0.005
Observational data: associations, not effects.
Further findings
| Outcome | IR | IS |
|---|---|---|
| Stress levels predicting negative affectβ ^ - | 0.08 | 0.08 |
| p | p<0.001 | p<0.001 |
Original publication
Daily life stress is linked to increased glucose levels in individuals with insulin resistance: a real-world assessment. Diabetologia. Published 11 October 2025. doi:10.
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