Adverse Cardiometabolic Outcomes in Men With Sisters With Polycystic Ovary Syndrome
Authors' conclusion
Having a sister with PCOS is associated with adverse cardiometabolic outcomes in men, already in early adulthood. Results contribute further knowledge on the familial impact of PCOS and highlight a patient group who may benefit from early screening and prevention.
Study context
- Population
- Men born in Sweden (1973–2013) with ≥1 sister, followed from age 5 until 31 December 2018
- Participants
- 1,098,203 men
- Exposure
- Men with a sister with polycystic ovary syndrome (PCOS) vs men with unaffected sisters
- Outcome
- Clinical diagnosis of obesity, T2D, or hypertension (Cox regression, adjusted for birth year and parental education)
Methodological detailslongitudinal, subcohort analysis at age 18 to 20 years
- Longitudinal
- Subcohort analysis at age 18 to 20 years
Main finding
As reported in the abstract
Clinical diagnoses of obesity, T2D and hypertension
Each group vs unaffected sistersEstimate (95% CI)
Sister with PCOS
aHR, obesity 2.02(1.85–2.21)
Sister with PCOS
aHR, T2D 1.62(1.34–1.96)
Sister with PCOS
aHR, hypertension 1.24(1.08–1.43)
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | |
|---|---|---|
| BMI and blood pressure categories in subcohort (n = 147 802; sister with PCOS n = 2970) · age 18 to 20 yearsSister with PCOSvs Unaffected sistersLogistic regression | aOR, overweight 1.33 (95% CI 1.19–1.49) | |
| BMI and blood pressure categories in subcohort (n = 147 802; sister with PCOS n = 2970) · age 18 to 20 yearsSister with PCOSvs Unaffected sistersLogistic regression | aOR, obese 1.78 (95% CI 1.47–2.15) | |
| 0.512Ratio (log scale) |
BMI and blood pressure categories in subcohort (n = 147 802; sister with PCOS n = 2970) · age 18 to 20 years
- Not associated with elevated blood pressure
Original publication
Adverse Cardiometabolic Outcomes in Men With Sisters With Polycystic Ovary Syndrome. J Clin Endocrinol Metab. Published 27 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →