Adult Thyroid Outcomes of Congenital Hypothyroidism
Authors' conclusion
Our results suggest that adults with thyroid dysgenesis on levothyroxine replacement therapy have relative triiodothyronine deficiency. Most adults with goitrous CH have genetic dyshormonogenesis. They are at high risk of developing thyroid nodules.
Study context
- Population
- Adult congenital hypothyroidism (CH) patients born after 1979, diagnosed by newborn screening, Ito Hospital, Tokyo, Japan103 adult CH patients
- Exposure
- Goiter vs Normal gland vs Dysgenesis; female CH patients vs TSH-matched non-CH women
- Female CHn = 56
- Non-CH womenn = 168reference
- Outcome
- Thyroid morphology and function: thyroid function tests and proportion with thyroid nodules
Methodological detailsobservational, single-centre
- Observational
- Single-centre
Main finding
As reported in the abstract
Thyroid function and nodules
| Group | Value | FT3/FT4 ratio | Thyroid nodules |
|---|---|---|---|
| Dysgenesis | 0.22 | 0.22 | |
| Female CH | 14.3% | 14.3% (8/56) | |
| Goiter | 71% | 71% (10/14) |
Value
Dysgenesis0.22
Female CH14.3%
Goiter71%
FT3/FT4 ratio
Dysgenesis0.22
Female CH— not stated in the abstract
Goiter— not stated in the abstract
Thyroid nodules
Dysgenesis— not stated in the abstract
Female CH14.3% (8/56)
Goiter71% (10/14)
- Significantly low serum FT3/FT4 ratio in Dysgenesis
- 0.22
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| Genetic defects in Goiter | Goiter 89% · thyroglobulin defect 33%, 3/9 · thyroid peroxidase defect 33%, 3/9 · dual oxidase 2 defect 22%, 2/9 |
- Genetic defects in Goiter: 8/9 genetically analysed
Original publication
Adult Thyroid Outcomes of Congenital Hypothyroidism. Thyroid. Published 21 April 2023. doi:10.
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