Relapse of Graves' disease in Chinese children: a retrospective cohort study
Authors' conclusion
GD children have a high relapse rate after remission, and most of them occur within 1 year. Thyroid function should be reexamined regularly after drug withdrawal. The response to medication and lifestyle of GD children may affect the prognosis.
Study context
- Population
- Newly diagnosed graves' disease (GD) children, Children's Hospital of Nanjing Medical University, 2013–2019
- Participants
- 204 participants
- Exposure
- Remission vs Relapse vs Continuing treatment
- Remissionn = 79reference
- Relapsen = 40
- Outcome
- Prognosis after regular treatment of GD (remission, relapse) and possible influencing factors
Methodological detailssingle-centre, All cases treated with methimazole at presentation
- Single-centre
- All cases treated with methimazole at presentation
Main finding
As reported in the abstract
Remission and relapse after remission
Remission
79
38.7%
Relapsed after remission
40
50.6%
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | |
|---|---|---|
| Factors associated with relapse (vs remission)Relapsevs Remission | aOR per additional month before FT4 fell into reference range 2.510 (95% CI 1.561–4.034) | |
| Factors associated with relapse (vs remission)Relapsevs Remission | aOR per additional hour of sleep duration per day 0.452 (95% CI 0.232–0.879) | |
| 0.20.5125Ratio (log scale) |
Safety
Switch from methimazole to PTU due to severe complications
- Changed medication to PTU
- 4 (2.0%)
Original publication
Relapse of Graves' disease in Chinese children: a retrospective cohort study. Eur Thyroid J. Published 19 April 2023. doi:10.
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