Adult Overweight and Obesity Management: Updates From the 2025 U.S. Department of Veterans Affairs and U.S. Department of Defense Clinical Practice Guidelines
Methodological detailsSystematic review of evidence 1 April 2019–6 January 2025 addressing 12 key questions (PICOTS); recommendations formulated using GRADE
- Systematic review of evidence 1 April 2019–6 January 2025 addressing 12 key questions (PICOTS); recommendations formulated using GRADE
Recommendations
As issued by the authors
- suggests
Routine screening for overweight and obesity in all adults based on BMI ≥25 kg/m² (≥23 kg/m² for Asian adults) with waist circumference and clinical context to refine risk
- strongly recommends
Comprehensive lifestyle intervention (CLI) as the foundation of care
- insufficient evidence
For or against delaying pharmacotherapy relative to CLI; no requirement to complete CLI before initiating additional treatments
Flexible, individualized integration of pharmacotherapy and CLI; discontinuation of effective medications discouraged to prevent weight regain
New and updated recommendations address medications containing GLP-1 RA, endoscopic therapies, and MBS
Original publication
Adult Overweight and Obesity Management: Updates From the 2025 U.S. Department of Veterans Affairs and U.S. Department of Defense Clinical Practice Guidelines. Ann Intern Med. Published 25 August 2026. doi:10.
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