Adult height improved over decades in patients with X-linked hypophosphatemia: a cohort study
Authors' conclusion
The FH of XLH patients in France increased significantly over the last decades. Even though men's FHs improved more than women's, men with XLH remain shorter reflecting a more severe disease phenotype. While the results are promising, most patients with XLH remain short leaving room for improvement.
Study context
- Population
- French patients with X-linked hypophosphatemia (XLH) with available final height measurements
- Participants
- 398 patients
- Exposure
- Final height across 3 birth-year groups
- Group 1n = 127
- Group 2n = 193
- Group 3n = 78
- Outcome
- Final height (height after cessation of growth) and its evolution over the last decades
Methodological detailsobservational
- Observational
Main finding
As reported in the abstract
Final height SDS
Group 1
−2.31
mean · SD 1.11 · standard deviation score (SDS)
Group 2
−1.63
mean · SD 1.13 · SDS
Group 3
−1.34
mean · SD 0.87 · SDS
P < 0.001
Observational data: associations, not effects.
Further findings
Final height in men
Final height in women
| Outcome | P value |
|---|---|
| Final height SDS by sexMale vs Female · lower in male | P = 0.002 |
- Final height SDS by sex: Male −2.08 (SD 1.18) SDS
- Final height SDS by sex: Female −1.70 (SD 1.12) SDS
Original publication
Adult height improved over decades in patients with X-linked hypophosphatemia: a cohort study. Eur J Endocrinol. Published 13 October 2023. doi:10.
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