Adrenal disease

Adrenal Venous Sampling Via an Antecubital Approach in Primary Aldosteronism: A Multicenter Study

J Clin Endocrinol MetabPublished Retrospective multicentre study

Authors' conclusion

This multicenter study demonstrates that AVS via an antecubital approach is safe and feasible, with a high rate of successful sampling, which may be an alternative to the femoral vein access method.

Study context

Population
Patients with PA who underwent adrenal venous sampling (AVS) via an antecubital approach, 7 Chinese medical centers, January 2012–December 2018; mean age 47.1 years, 57.9% male
Participants
1,226 patients
Outcome
Success rate of AVS via an antecubital approach (selectivity index >2)
Methodological detailsmulticenter, 7 Chinese medical centers
  • Multicenter
  • 7 Chinese medical centers

Main finding

As reported in the abstract

Sampling success rate

Bilateral sampling success

91.5%

Right sampling success

94.9%

Left sampling success

95.1%

Observational data: associations, not effects.

Further findings

Success rate, initial 70 cases vs subsequent cases

Bilateral: initial 70 cases vs subsequent
82.9% vs 92.0% (P = .012)
Right: initial 70 cases vs subsequent
87.1% vs 95.3% (P = .008)
Left: initial 70 cases vs subsequent
88.6% vs 95.5% (P = .018)
  • Initial 70 cases = initial 10 cases at each center

Puncture site and access change

Right antecubital vein
1211 (98.8%)
Left antecubital vein
15 (1.2%)
Changed to right femoral vein (cannulation failure or adrenal vein anatomic variation)
6 (0.5%)

Safety

Adrenal vein rupture, no sequelae
5 patients (0.41%)

Original publication

Adrenal Venous Sampling Via an Antecubital Approach in Primary Aldosteronism: A Multicenter Study. J Clin Endocrinol Metab. Published 19 July 2023. doi:10.1210/clinem/dgad433

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