Admission hyperglycemia, stroke subtypes, outcomes in acute ischemic stroke
Authors' conclusion
Hyperglycemia was differently associated with the risk of 3-month stroke by ischemic stroke subtype. The associations of hyperglycemia with 3-month stroke were greatest in CE subtype but not in SVO subtype. These results suggest that the effect of glucose-lowering treatment after AIS may differ according to stroke subtype.
Study context
- Population
- Patients with acute ischemic stroke (AIS) in a multicenter prospective stroke registry; age 69.0±12.6 yrs, male 58.4%; subtypes large artery atherothrombosis (LAA), cardioembolism (CE), small vessel occlusion (SVO)
- Participants
- 32,772 patients
- Exposure
- Admission hyperglycemia categories by ischemic stroke subtype
- Outcome
- Early vascular outcomes: stroke, all-cause mortality, and composite of stroke, MI and all-cause mortality; interaction of hyperglycemia with stroke subtype
- Follow-up
- 3 months
Methodological detailsmulticenter, prospective stroke registry
- Multicenter
- Prospective stroke registry
Main finding
As reported in the abstract
- Interaction for 3-month stroke
- Pinteraction = 0.003
- Interaction for composite of stroke, MI and all-cause mortality
- Pinteraction = 0.001
Observational data: associations, not effects.
Further findings
Distribution of glucose groups · admission
Original publication
Admission hyperglycemia, stroke subtypes, outcomes in acute ischemic stroke. Diabetes Res Clin Pract. Published 12 January 2023. doi:10.
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