Adjustment of the ACEF score by the triglyceride glucose index improves the prediction of clinical outcomes in patients undergoing percutaneous coronary intervention
Authors' conclusion
The combination of the TyG index and the ACEF score enhances the predictive ability for long-term MACCEs in patients with CHD undergoing PCI.
Study context
- Population
- Patients with CHD who underwent PCI at the Third People's Hospital of Chengdu, China, May 2018–December 2022
- Participants
- 1,248 patients
- Exposure
- High vs low ACEF score and triglyceride-glucose (TyG) index; ACEF + TyG added to conventional risk model
- Outcome
- MACCEs
- Follow-up
- Median 30.60 months
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Hazard ratio (95% CI)P value
ACEF >1.27Kaplan-Meier;vs lower ACEF
2.018(1.593–2.789)
Log-Rank test, P < 0.001TyG >8.82Kaplan-Meier;vs lower TyG
2.057(1.572–2.691)
Log-Rank test, P < 0.001ACEF scoremultivariable Cox
1.702(1.210–2.394)
P = 0.002TyG indexmultivariable Cox
1.575(1.296–1.916)
P < 0.001- Patients with major adverse cardiac and cerebrovascular events (MACCEs)
- 214
Observational data: associations, not effects.
Further findings
Incremental prediction of MACCEs: ACEF + TyG added to conventional risk model
- C-statistic
- 0.664 to 0.703
- Continuous net reclassification improvement (NRI)
- 0.391
- Categorical NRI
- 0.107
- Integrated discrimination improvement (IDI)
- 0.033
- P (all)
- P < 0.001
Original publication
Adjustment of the ACEF score by the triglyceride glucose index improves the prediction of clinical outcomes in patients undergoing percutaneous coronary intervention. Cardiovasc Diabetol. Published 18 December 2024. doi:10.
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