The relationship between atherogenic index of plasma and plaque vulnerabilities: an optical coherence tomography study
Main finding · Prevalence of thin-cap fibroatheroma (TCFA)Result — go to the resultOdds ratio 11.130 95% CI 4.186–29.593Authors' conclusion
AIP is an independent predictor for vulnerable plaques beyond traditional factors. It can be integrated in clinical practice for risk stratification of ACS patients.
Study context
- Population
- Patients with acute coronary syndrome (ACS) undergoing pre-intervention optical coherence tomography (OCT), January 2016 to June 2017; Atherogenic index of plasma (AIP) = log10(TG/HDL-C)332 analysed
- Participants
- 522 patients
- Exposure
- AIP quartiles
- Outcome
- Prevalence of thin-cap fibroatheroma (TCFA)
Methodological detailsoptical coherence tomography, pre-intervention
- Optical coherence tomography
- Pre-intervention
Main finding
As reported in the abstract
Odds ratio
11.130
95% CI 4.186–29.593
P < 0.001
By group
Group IVvs Group I
OR 11.130 (95% CI 4.186–29.593); P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | Group I | Group II | Group III | Group IV | OR (95% CI) | P value | |
|---|---|---|---|---|---|---|---|
| Plaque ruptureGroup IVvs Group IMultivariate logistic regression | 10.4% | 14.1% | 17.6% | 34.1% | 5.332 (2.040–13.937) | P < 0.001 | |
| 0.050.21520Odds ratio (log scale) |
Macrophage accumulation
Plaque erosion
Plaque rupture
- Significantly different among AIP quartiles
Macrophage accumulation
- Significantly different among AIP quartiles
Plaque erosion
- Significantly different among AIP quartiles
Predictive value (ROC) of AIP
- AIP for thin-cap fibroatheroma (TCFA)
- 0.720
- AIP for plaque rupture
- 0.669
Original publication
The relationship between atherogenic index of plasma and plaque vulnerabilities: an optical coherence tomography study. Cardiovasc Diabetol. Published 18 December 2024. doi:10.
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