Adiposity and metabolic health in Asian populations: an epidemiological study using dual-energy x-ray absorptiometry in Singapore
Authors' conclusion
Visceral adiposity is an independent risk factor for metabolic disease in Asian populations, and accounts for a large fraction of type 2 diabetes cases in each of the ethnic groups studied. However, the variation in insulin resistance and type 2 diabetes risk between Asian subgroups is not consistently explained by adiposity, indicating an important role for additional mechanisms underlying the susceptibility to cardiometabolic disease in Asian populations.
Study context
- Population
- Multiethnic Asian men and women living in Singapore, aged 30–84 years, HELIOS cohort, with DXA body composition and metabolic characterisation; mean age 52.8 years, 59.6% femaleof 10,004 consented
- Participants
- 9,067 men
- Exposure
- Asian ethnic subgroups (Malay, Indian vs Chinese); BMI and visceral fat mass index (vFMI) vs cardiometabolic outcomes
- Chinesen = 6,224reference
- Malayn = 1,169
- Indiann = 1,674
- Outcome
- Prevalence of T2D, hypercholesterolaemia and hypertension
Methodological detailspopulation-based cohort (HELIOS), multiethnic, DXA body composition, multivariable regression, Between April 2, 2018, and Jan 28, 2022
- Population-based cohort (HELIOS)
- Multiethnic
- DXA body composition
- Multivariable regression
- Between April 2, 2018, and Jan 28, 2022
Main finding
As reported in the abstract
- T2D prevalence
- 8.2% (n=744)
- Hypercholesterolaemia prevalence
- 27.2% (n=2469)
- Hypertension prevalence
- 18.0% (n=1630)
- Malay and Indian vs Chinese participants: odds of obesity and T2D
- 3-4-times higher
- Excess adiposity associated with adverse cardiometabolic health indices including T2D
- p<0.0001
Observational data: associations, not effects.
Original publication
Adiposity and metabolic health in Asian populations: an epidemiological study using dual-energy x-ray absorptiometry in Singapore. Lancet Diabetes Endocrinol. Published 29 August 2024. doi:10.
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