The coexistence of low muscle mass and obesity evaluated by dual energy X‐ray absorptiometry, rather than low muscle mass or obesity alone, is associated with macrovascular but not microvascular complications in patients with type 2 diabetes mellitus
Authors' conclusion
According to our findings, the coexistence of low muscle mass and obesity, rather than low muscle mass or obesity alone, was significantly associated with a higher prevalence of macrovascular complications in hospitalized patients with T2DM. This association was not observed for diabetic microvascular complications.
Study context
- Population
- Hospitalized patients with T2D; body composition by DXA
- Participants
- 2,387 patients
- Exposure
- Body composition patterns by DXA: low muscle mass, obesity, and coexistence of low muscle mass and obesity vs control
- Outcome
- Macrovascular and microvascular complications of diabetes
Methodological detailshospitalized patients, multiple logistic regression
- Hospitalized patients
- Multiple logistic regression
Main finding
As reported in the abstract
Macrovascular complications
Each group vs controlOdds ratio (95% CI)
Low muscle mass
0.62(0.27–1.39)
Obesity
1.12(0.59–2.11)
Low muscle mass and obesity
2.43(1.16–5.07)
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| Microvascular complicationsLow muscle massvs ControlAdjusted · adjusted for potential confounders | 0.86 (0.52–1.43) | |
| Microvascular complicationsObesityvs ControlAdjusted · adjusted for potential confounders | 0.82 (0.53–1.26) | |
| Microvascular complicationsLow muscle mass and obesityvs ControlAdjusted · adjusted for potential confounders | 1.21 (0.69–2.15) | |
| 0.512Odds ratio (log scale) |
Original publication
The coexistence of low muscle mass and obesity evaluated by dual energy X‐ray absorptiometry, rather than low muscle mass or obesity alone, is associated with macrovascular but not microvascular complications in patients with type 2 diabetes mellitus. Diabetes Obes Metab. Published 30 September 2024. doi:10.
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